The introduction of SENP1 expression induces deSUMOylation of NPM-ALK, and the subsequent ubiquitination and proteasomal degradation of NPM-ALK, decreasing the viability, proliferation and anchorage-independent colony formation in NPM-ALK+ T-cell lymphoma cell lines. The gene discussed is SENP1; the disease is T-cell non-Hodgkin lymphoma.