Next, we determined CPE gene transfer mediated selective tumor cell killing in Cldn3/4 positive Capan-1, PA-TU-8902, AsPc-1, MIA PaCa-2, BxPC-3 and HUP-T3 cells as well as the negative control cell line SK -MEL-5 and the positive control line HT-29. The gene discussed is CLDN3; the disease is neoplasm.