In the Cldn3/4 low expressing MIA PaCa-2/eGFP-Luc tumors non-viral optCPE gene transfer led to significant reduction of tumor viability (p = 0.0336) and tumor volume (p < 0.0001) compared to vector control (VC) treated mice (Figure 6A,B). Here, CLDN3 is linked to neoplasm.