PNPLA3 and fatty liver disease: Hepatocyte-specific overexpression of PNPLA3 I148M variant accelerates steatohepatitis and led to liver fibrosis in a diet-induced animal model of NAFLD that sequentially developed a fatty liver, steatohepatitis, and progression of fibrosis on a high-fat diet (HFD) with the provision of sugars in the drinking water (named DIAMOND mouse model) [54].