Along with the somatic mutations that occur in this gene, during the beginning and advance of the tumor, in the 30% of HCC cases mutations in the oncosuppressor TP53 and in the CTNNB1 genes have been observed, coding for the beta catenin and component of the Wnt pathway, together with the axis inhibition protein1 (AXIN1), found in the 10% of cases [35]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.