CD4 and hepatocellular carcinoma: Further, although the frequency of circulating CD4+ CD25+ CD127− Tregs has been found to be much lower in HCC patients than in healthy donors and patients of chronic HBV infection, HCC resection by surgery has been found to be associated with a significant increase in the frequency of circulating CD4+ CD25+ CD127− Tregs in HCC patients, that seems to be correlated with tumor aggressiveness [126].