Mutational events in key genes, such as TERT, TP53, CTNNB1, MYC, RB1, AXIN1, and genes involved in chromatin remodeling, such as ARID1A, ARID2, and BAP1, were found to be associated with the malignant transformation process in HCC by TCGA analysis [34]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.