Finally, HCC-derived CAFs are involved in the regulation of the viability and functionality of neutrophils through the involvement of the IL6-STAT3-PDL1 signaling pathway and through the induction of chemotaxis of neutrophils as demonstrated by a study that deepened the effects and role of HCC-derived CAFs on the neutrophils [88]. The gene discussed is STAT3; the disease is hepatocellular carcinoma.