Combinations of miR-511 and miR-503 (sensitivity 100%, specificity 93%) [111], miR-511 and miR-184 (sensitivity 100%, specificity 80%) [111] and miR-483-3p with the immunohistochemical marker Smad4 (specificity 92.8%) [116] can possibly distinguish ACC from ACC as well. The gene discussed is SMAD4; the disease is adrenal cortex carcinoma.