MAD2L1 and adrenal cortex carcinoma: Additionally, the combination of IGF-2 with other markers, such as Ki67, MAD2L1 or CNNB1 expression can be used to diagnose ACC, as these combinations provide a sensitivity of 96%, 100% and 91% and a specificity of 100%, 95% and 100% for diagnosing ACC, respectively [60].