Genome-wide studies comparing methylation in ACC and benign adrenal tissues show both global hypomethylation and hypermethylation of CpG-islands of genes involved in apoptosis regulation, transcription regulation and cell cycle control, such as CDKN2A, GATA4, BCL2, DLEC1, HDAC10, PYCARD, SCGB2A1/HIN1, KCT12, KIRREL, SYNGR1, NTNG2 and the imprinting region with IGF2 and H19 on chromosome 11p15 [97,98,99]. Here, H19 is linked to adrenal cortex carcinoma.