TP53 and adrenal cortex carcinoma: Frequently altered genes in ACC include TP53 (~16–36%), ZNRF3 (~19–21%), CTNNB1 (~16–19%), CDKN2A (~11–15%), TERT (~6–14%), PRKAR1A (~11%), RB1 (~7%), MEN1 (~7%), DAXX (~6%), ATRX (~4%), MDM2 (~4%) and CDK4 (~2%) [139,143,149].