IGF2 and adrenal cortex carcinoma: Interestingly, a specific juxtanuclear Golgipattern of IGF-2 expression is seen in ACC, which is most likely caused by impairment of translation and processing of IGF-2 molecules within the Golgi apparatus, leading to decreased secretion of mature IGF-2 and increased secretion of heavier precursor forms [56,58,84,92,93].