It should be noted that in some PB samples from HD, a population of Tαβ cells apparently showing very dim expression of TRBC1 was detected, even at different centers, (e.g., Salamanca and Porto), without paralleled low expression of CD3 (data not shown); this could be due to nonspecific labeling or any other nonidentified technical issue related to CD3/TCRVβ and TRBC1 interactions, this population being here considered as TRBC1−. The gene discussed is TRBC1; the disease is Huntington disease.