In this regard, here we show that assessment of the pattern of expression of TRBC1 in small populations of phenotypically aberrant Tαβ-cells from patients with distinct subtypes of T-CLPD provides a level of detection of ≤10−4, similar to that obtained once tumor-associated TCRVβ family-specific antibodies are used, as demonstrated by real and virtual dilutional experiments. Here, TRBC1 is linked to neoplasm.