Interestingly, while in T-PLL (postulated to derive from naïve/central memory cells) TRBC1+ only represented three of 10 (30%) cases investigated, among primary cutaneous T-cell lymphoma (PCTCL)-Sézary syndrome (SS) TRBC1+ cases represented 80% (12 of 15) of the patients, respectively (Table 5). The gene discussed is TRBC1; the disease is Sezary syndrome.