PCS3 samples were highly mutated in SLIT2 and ROBO1. Bailey et al. in the previous pancreatic cancer studies demonstrated that ROBO/SLIT signaling pathways play contradictory and anti-angiogenic roles in tumorigenesis, endometriosis and renal ischemia-reperfusion injury [9,60,61,62,63]. Here, SLIT2 is linked to endometriosis.