Furthermore, the treatment of NB cell lines with the cytokines IFNγ and TNFα, known to upregulate Fas expression [47,48,49,50,51,52] through NF-Kb induction [53,54], enhanced the NK-cell-mediated apoptosis but not the NK-cell-mediated degranulation. This evidence concerns the gene NFKB1 and neuroblastoma.