Accordingly, all NB cell lines treated with IFNγ and TNFα (with the exclusion of SK-N-BE(2)c) were significantly more susceptible to NK-cell-mediated apoptosis than untreated cells (Figure 3C), whereas the cytokine treatment alone did not affect the apoptotic status of NB cell lines (Figure S4B). This evidence concerns the gene TNF and neuroblastoma.