In addition, we evaluated the effect of two cytokines IFNγ and TNFα, known to upregulate Fas [47,48,49,50,51,52] through the activation of NF-Kb [53,54], on both the surface expression of activating ligands and FAS and on NK-cell-mediated apoptosis and recognition of NB cell lines. This evidence concerns the gene TNF and neuroblastoma.