To assess the correlation between Fas, PVR, and the NF-kB p65 subunit, the status of genes encoding Fas (FAS, chromosomal coordinates chr10: 88,968,429–89,017,059; cytoband 10q23.31), PVR (PVR, chromosomal coordinates chr19: 44,643,798–44,666,162; cytoband 19q13.31), and p65 (RELA, chromosomal coordinates chr11: 65,653,597–65,663,090; cytoband 11q13.1) was evaluated in a panel of 11 NB cell lines, including MYCN non-amplified (SH-SY-5Y, ACN, SK-N-AS, and SH-EP), MYCN gain (SK-N-SH and GICAN), and MYCN-amplified (LA-N-5, SMS-KCNR, IMR-32, SK-N-BE(2)c, and LA-N-1). This evidence concerns the gene MYCN and neuroblastoma.