Herein, we provided evidence that the transfection of NB cells with the p65 subunit, a component of the NF-kB heterodimer that is known to directly regulate the expression of both Fas [36,37] and PVR [46], enhanced the NB susceptibility to NK-cell-mediated killing through DNAM-1 and FasL engagement as demonstrated by blocking experiments. This evidence concerns the gene CD226 and neuroblastoma.