In contrast, p65-overexpressing SK-N-BE(2)c cells were recognized similarly to the pcDNA3-SK-N-BE(2)c control cells, thus suggesting that the upregulation of Fas and PVR, through the overexpression of the p65 subunit, specifically increased the susceptibility of MYCN-amplified NB cell lines to NK-cell-mediated apoptosis, recognition, and killing. The gene discussed is FAS; the disease is neuroblastoma.