NECTIN2 and neuroblastoma: By contrast, the cytokine treatment induced the downregulation of ULBP2/5/6 in SH-SY-5Y and LA-N-5, of ULBP-3 in SH-SY-5Y, of Nectin-2 in SH-SY-5Y, ACN, and LA-N-5, and of TRAIL-R2 in all NB cell lines with the exception of SK-N-BE(2)c (Figure S4A).