In addition to chromosomal aberrations such as the MYCN amplification conferring proliferative and metastatic abilities to tumor cells [73], NB cells adopt several molecular strategies to evade the immune control, including the downregulation of ligands for NK-cell-activating receptors, thus preventing proper NK-cell-mediated recognition and killing of NB cells [8,74]. This evidence concerns the gene MYCN and neuroblastoma.