The upregulation of Fas and PVR was more evident in MYCN non-amplified NB cell lines (with the exception of Fas in SK-N-AS) than in those MYCN-amplified, as also confirmed by RT-PCR (Figure S3), thus suggesting that the MYCN amplification might affect the p65-mediated induction of both Fas and PVR. The gene discussed is MYCN; the disease is neuroblastoma.