Accordingly, several molecules aimed at stimulating NF-kB such as TNFα [84], retinoids [85,86], betulinic acid [87], Nedd4 binding protein 1 (N4BP1) [88], and IL-17 [89] are being investigated for novel immunotherapies of solid cancer, including NB [86,88]. This evidence concerns the gene N4BP1 and neuroblastoma.