We identified two case series and 34 case reports in the current literature, comprising 39 cases of primary ALCL of the CNS with information on ALK status and treatment courses (Table 1) [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.