The replacement of miR-149, normally suppressed by SNAIL2 in colon carcinoma, was associated with an inhibition of EMT and 5-FU chemo-resistance upon the targeting of MYC and nanog homeobox (NANOG) [23] and with a reduction in glucose metabolism after pyruvate dehydrogenase kinase 2 (PDK2) inhibition [24]. The gene discussed is PDK2; the disease is colon carcinoma.