Its ectopic expression determined a decrease of CRC aggressiveness in vitro and of a resistance to 5-FU and CDDP by suppressing the ETS proto-oncogene 1 transcription factor (ETS1)/transglutaminase 1 (TGM1) axis and the Wnt/β-catenin pathways [63]. Here, TGM1 is linked to colorectal carcinoma.