TWIST1 and colorectal carcinoma: Consistently, the loss of miR-200 and miR-141 were related to the overexpression of the zinc finger E-box-binding homeobox 1 (ZEB1) and snail family transcriptional repressor 2 (SNAI2) (targeted by miR-200a, miR-200b and miR-141) and twist family bHLH transcription factors (TWIST) (targeted by miR-200c and miR-141), all contributing to the epithelial–mesenchymal transition (EMT) in 5-FU-resistant CRC [6].