MiR-372/373 acted as promoters of stemness and 5-FU resistance in CRC cells by silencing the genes implicated in the differentiation process, such as the speckle-type BTB/POZ protein (SPOP), SET domain containing 7, histone lysine methyltransferase (SETD7) and vitamin D receptor (VDR) targets [39]. The gene discussed is VDR; the disease is colorectal carcinoma.