SERPINE1 and cancer: CBD inhibits MMP 2, MMP 9, and tissue inhibitor of metalloproteinase 1, which results in the suppression of cell motility and the invasion of endothelial cells; also, CBD inhibits urokinase-type plasminogen activator (uPA) and serpin E1/plasminogen activator inhibitor 1, which are involved in the degradation of the extracellular matrix and contribute to cancer cell invasiveness.