One of the studies showed that ingestion of high-tetrahydrocannabinolic acid (THCA) cannabis extract caused inhibition of COX-2, matrix metalloproteinase-9 (MMP-9), and alleviated inflammatory response via GPR55 receptors, resulting in anti-inflammatory effects in cell culture experiments and in IBD patients’ biopsy material [34]. This evidence concerns the gene MMP9 and inflammatory bowel disease.