The DLD-1 CRC xenograft model had higher CB2 levels of expression, and treatment with CB2 agonist such as N-cyclopentyl-7-methyl-1-(2-morpholin-4-ylethyl)-1,8-naphthyridin-4(1H)-on-3-carboxamide (CB13) significantly decreased tumors in size [12]. Here, CNR2 is linked to colorectal carcinoma.