Cannabinoids may reduce colonic polyp formation, intestinal inflammation, and reduce cancer cells growth via cannabinoid 1 (CB1), cannabinoid 2 (CB2) receptors, transient receptor potential cation channel subfamily V member 1 (TRPV1) receptors, and G-coupled protein receptor 55 (GPR55) [12,20,28,30,31,32,33,34,35,36]. Here, GPR55 is linked to polyp.