BRCA1 and cancer: On the other hand, high-ITH cancers might correspond to TNBC (with basal-like carcinomas as one of its subtypes) that have a much worse prognosis and are characterized by a significantly higher frequency of genetic aberrations and pathogenic single nucleotide mutations (BRCA1/2, TP53) than other types of breast carcinomas [40,44,53,54].