BRCA1 and neoplasm: Tumour BRCA1/BRCA2 testing in 116 Manchester cases identified 7 (6%) BRCA1 and 5 (4.3%) BRCA2 somatic PVs as well as 1 (0.9%) BRCA1 and 1 (0.9%) BRCA2 somatic VUS each (Table 5).