It is worth mentioning that genetic polymorphisms of both ABCB1 and ABCG2 in relevance to HCC susceptibility, HCC risk of recurrence following liver transplantation [53] as well as a therapeutic response [58] have been thoroughly studied which provide a solid ground for how genetic variability can implicate HCC since its incidence till therapeutic response. This evidence concerns the gene ABCG2 and hepatocellular carcinoma.