Furthermore, Alonso-Pena et al. have identified several SLC22A1 inactivating variants at a high frequency in HCC such as rs1001179 (c.262T > C), rs34104736 (c.566C > T), rs36103319 (c.659G > T) and rs4646278 (c.859C > G). The gene discussed is SLC22A1; the disease is hepatocellular carcinoma.