Comparable mutation rates were seen in UTUC and bladder UC, with a strong APOBEC signature, but FGFR3, chromatin remodeling gene such as KMT2D, and CDKN2A were mutated at a higher frequency in UTUC compared in bladder UC [4]. The gene discussed is CDKN2A; the disease is renal pelvis/ureter urothelial carcinoma.