Notably, while TLR4-mediated signaling was demonstrated to promote liver fibrosis and fibrosis-associated tumorigenesis [53,57], TLR2 stimulation by LTA, in conjunction with the action of the secondary BA deoxycholate (DCA; a reported inducer of DNA damage [58] and apoptosis [59], was implicated in obesity-associated HCC [56]. The gene discussed is TLR2; the disease is obesity disorder.