Another chromosomal translocation t(15;17) was detected in acute promyelocytic leukemia (APL), resulting in the formation of promyelocytic leukemia–retinoic acid receptor α (PML-RARα) fusion oncoprotein that can interplay with retinoic X receptors (RXR) and promote the deregulation of epigenetic modifications [31,32,33]. The gene discussed is RARA; the disease is acute promyelocytic leukemia.