TGFB1 and neoplasm: The role of TGFβ in promoting tumor development and metastasis, combined with the liberation of TGFβ during periods of tumor induced osteolysis has been well documented, leading to the examination of TGFβ inhibition via soluble decoy receptors, small molecule inhibitors, and antisense oligonucleotides as a potential therapeutic target for patients with bone metastasis [115].