Ectopic expression of Runx2 also induces osteomimicry whereby cancer cells produce proteins typically reserved for skeletal development such as RANKL, osteoprotegrin, and matrix metalloproteinases 9 and 13, which disrupts the homeostasis of the bone microenvironment and promotes osteoclast activity while suppressing osteoblasts [55]. The gene discussed is RUNX2; the disease is cancer.