Precisely because of the above-mentioned facts, the goals of our study were (i) to determine the expression of IMP3 in benign laryngeal lesions, low and high-grade dysplasia, and LSCC; (ii) correlate its expression with other markers of cell growth and proliferation (Ki-67, p53 and cyclin D1); (iii) determine pathological–clinical features of the tumor with IMP3 overexpression and (iv) its influence on disease outcome of patients with laryngeal squamous cell carcinoma. Here, IMP3 is linked to laryngeal squamous cell carcinoma.