RELA and cancer: This is further supported by our finding that LGR6 was downregulated upon loss of RelA/p65, most likely resulting in the suppression of Wnt/β-catenin signalling implicated in the induction of cancer stem cells and metastasis, suggesting that this may be another mechanism by which canonical NF-κB modulates Wnt signalling, cancer stem cell expansion and metastasis of lung cancer cells [37,38].