More specifically, as shown in the Venn diagrams and the heat maps, upon RelA/p65 knock-down, 13 genes in common were upregulated and 10 genes in common were downregulated (CHL1, LGR6, FAM20A, PLAU, DEFB1, CYP2C9, ANXA10, ROS1, C1R, and C1S) in the A549 and H1437 tumours. This evidence concerns the gene C1S and neoplasm.