More specifically, as shown in the Venn diagrams and the heat maps, upon RelA/p65 knock-down, 13 genes in common were upregulated and 10 genes in common were downregulated (CHL1, LGR6, FAM20A, PLAU, DEFB1, CYP2C9, ANXA10, ROS1, C1R, and C1S) in the A549 and H1437 tumours. The gene discussed is C1R; the disease is neoplasm.