Using genetic approaches to inducibly express KRASG12D in CC10+ and Sftpc+ AT-II epithelial cells of the adult mouse lung, it was found that AT-II and Clara cells in the terminal bronchioles, and bronchoalveolar stem cells were identified as cells of origin for K-RasG12D-induced lung hyperplasia and carcinomas, but only AT-II cells were identified as the predominant cell of origin of LUAD induced by K-RasG12D activation [8,9,65,66]. Here, SFTPC is linked to carcinoma.