Amongst the common upregulated genes was the metastasis suppressor gene CD82/KAI1 encoding a tetraspanin (TSPAN27) [39,40,41], and amongst the common downregulated genes was the proto-oncogene ROS1 encoding an orphan type I transmembrane Receptor Tyrosine Kinase (RTK) [42], both of which have been implicated in lung cancer (Figure 2). The gene discussed is ROS1; the disease is lung cancer.