CHL1 and neoplasm: More specifically, as shown in the Venn diagrams and the heat maps, upon RelA/p65 knock-down, 13 genes in common were upregulated and 10 genes in common were downregulated (CHL1, LGR6, FAM20A, PLAU, DEFB1, CYP2C9, ANXA10, ROS1, C1R, and C1S) in the A549 and H1437 tumours.