The most frequently altered genes are TP53 (72%), CDKN2A (28%), KRAS (19%), MYC (19%), ERBB2 (18%), GATA4 (15%), SMAD4 (15%), CCND1 (14%), GATA6 (14%), CDK6 (14%), ARID1A (13%) and EGFR (12%) (with GATA4 and GATA6 not meeting the general cancer genome criteria for oncogenes or tumor suppressor genes, respectively (https://cancer.sanger.ac.uk/census, accessed on 2 August 2021). This evidence concerns the gene SMAD4 and cancer.