PRSS21 and colorectal cancer: DTA selected the following genes as important indicators of colorectal cancer: ABCA12, CLDN18, MAGEA11, MAGEA6, MTRNR2L1, MTTP, NPC1L1, PRSS21, SLC14A1, and SPESP1. CLDN18 encodes the gastric type adhesion molecule and is a known biomarker for gastric cancer [24].