CD274 and non-small cell lung carcinoma: Here, we developed a novel Boolean implication network scheme to model CNV and gene expression (GE) profiles in NSCLC tumors (n = 371) to decipher molecular networks for CD27, and dissect those involving CD27, PD1, and PDL1. Such revelation will provide insights into molecular mechanisms underlying immunotherapy targeting CD27 alone, or in combination with the PD1/PDL1-blockade.