Here, we developed a novel Boolean implication network scheme to model CNV and gene expression (GE) profiles in NSCLC tumors (n = 371) to decipher molecular networks for CD27, and dissect those involving CD27, PD1, and PDL1. Such revelation will provide insights into molecular mechanisms underlying immunotherapy targeting CD27 alone, or in combination with the PD1/PDL1-blockade. The gene discussed is CD27; the disease is non-small cell lung carcinoma.