Based on the identified multi-omics network of CD27, PD1, and PDL1, proliferation genes were identified from CRISPR-Cas9 (n = 78) and RNAi (n = 92) screening data; prognostic genes were selected and validated in NSCLC tumors (n = 1163). This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.