▪Soluble immune-related biomarkers.▪Levels of IFNγ, TNF and IL are associated with ICI benefit.▪Interleukins are involved in key mechanisms of tumorigenesis.▪High concentrations of IL-8 associated with worse PFS in kidney cancer patients treated with tyrosine kinase inhibitors.▪Disadvantages: Although the analysis is protocolized, more studies are needed. This evidence concerns the gene IFNG and kidney cancer.