In the metastatic lymph node from a gastric cancer HGC-27 cell line, MAGI2-AS3 overexpression might be caused by the transcriptional regulator bromodomain containing 4 (BRD4) and its interaction with histone H3 acetylated at lysine 27, enriched in the promoter region MAGI2-AS3 [225]. The gene discussed is BRD4; the disease is gastric cancer.