In esophageal cancer, MAGI2-AS3 can down-regulate HOXB7 expression by recruiting the histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) to promote the tri-methylation of lysine 27 on histone H3 in the HOXB7 promoter region. The gene discussed is EZH2; the disease is esophageal cancer.