In the context of epithelial ovarian cancer, specifically high-grade serous ovarian carcinoma, MAGI2-AS3 acts as a tumor suppressor by sponging miR-15b-5p, miR-374a-5p, and miR-374b-5p, and may regulate the expression of their target mRNAs PTEN, RECK, Metastasis suppressor protein 1 (MTSS1), Homeobox -A5 (HOXA5) [209]. Here, MTSS1 is linked to ovarian serous carcinoma.