This suggests it is not the inhibitory signal provided by SIRPα binding to CD47 on these tumor cells that hampers neutrophil-mediated ADCC, but rather an insufficient tumor cell opsonization due to low GD2 expression is limiting the full cytotoxic capacity of neutrophils towards dinutuximab-opsonized SHEP-2 and SK-N-AS cells. The gene discussed is SIRPA; the disease is neoplasm.