Genomic profiling of 32 clinical samples and 5 ALCL cell lines by microarray analysis identified overexpression of the BCL6, PTPN12, CEBPB and SERPINA1 genes in ALK-positive ALCL, whereas the CCR7, CNTFR, IL-22 and IL-21 genes were overexpressed in ALK-negative ALCL. This evidence concerns the gene BCL6 and anaplastic large cell lymphoma.