In rare ALK- ALCL subsets, chromosomal rearrangements creating chimeras combining a transcription factor (NFkB2 or NCOR2) with a tyrosine kinase (ROS1 or TYK2) were found to elicit STAT3 phosphorylation independent of JAK1 or STAT3 mutations [50]. This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.