TGFB1 and neoplasm: Additionally, M2-like TAMs secrete IL-10 and TGF-β that play critical roles in tumor immune evasion by inhibiting Th1 and cytotoxic T cell effector molecules, inhibiting antigen presentation by downregulating MHC class II on glioma cells, and attracting immune-suppressive Tregs and MDSCs [27,111,121,122,123,124].