To determine the status of cell cycle arrest and apoptosis after combination treatment, five DLBCL cell lines (EZH2 WT: SU-DHL-16, HBL-1 and U2932; EZH2 MT: KARPAS-422 and SU-DHL-6) were analyzed by flow cytometry and Western blot. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.