EZH2 and neoplasm: Two cell-derived xenograft models (U2932: EZH2 WT; SU-DHL-6: EZH2 Y641N) and two patient-derived xenograft models (PDX001: EZH2 WT; PDX002: EZH2 Y641N) were used to assess the anti-tumor activity of drug combination in vivo.