Previous studies have reported that chloroquine induced EBV lytic reactivation by activating TRIM28 phosphorylation at serine 824 in Burkitt’s lymphoma cells, with the resultant ATM-dependent TRIM28 phosphorylation being required for the upregulation of BZLF1 and EA-D in Burkitt’s lymphoma and lymphoblastoid cells [41]. This evidence concerns the gene COLQ and Burkitt lymphoma.