Interferon-γ (IFN-γ) is the major inducer of three CXCR3 ligands, monokine induced by IFN-γ (MIG)/CXCL9, 10 kDa IFN-γ-induced protein (IP-10)/CXCL10 and IFN-inducible T cell α chemoattractant (I-TAC)/CXCL11 in mainly endothelial cells, monocytes, fibroblasts, and cancer cells. This evidence concerns the gene IFNG and cancer.