Tsai et al. [162] combined trimethyl chitosan, TMC (possessing excellent mucoadhesive and absorption-enhancing properties), with fucoidan, FD (possessing hypoglycemic effects and capacity to prevent diabetes-related complications), to develop a multifunctional nanoplatform for enhancing the transepithelial permeation of insulin through the intestinal epithelial cell barrier and inhibiting the α-glucosidase activity. This evidence concerns the gene INS and diabetes mellitus.