In comparison, our data shows only a mild increase in Il-10 levels, which can be explained by the myeloid-specific Cdk5 deletion compared with the total deletion of the Cdk5 activator p35 from Seok et al. In addition, the enhanced c-Maf level resulted in significantly reduced Ccl5, Mcp1, Ccl3 (Mip1a), and Tnf-α plasma levels and tended to reduce Il-1a and Ccl4 (Mip1b) plasma levels in the Cdk5LysMCre mice after endotoxemia, suggesting better resolution of inflammation. This evidence concerns the gene CCL4 and serum lipopolysaccharide activity.