Consistent with these findings, we observed decreased levels of pro-inflammatory cytokines such as Il-1a, Ccl5 (Rantes), Mcp1, Ccl3/Ccl4 (Mip1a/b), as well as Tnf-α in Cdk5LysMCre mice compared with Cdk5flox littermates during LPS-induced endotoxemia (Supplementary Figure S3A–F). This evidence concerns the gene CCL5 and serum lipopolysaccharide activity.