SF3B1 and thrombocytosis disease: Among the CH mutations, genes encoding Additional sex combs like 1 (ASXL1) [153], Splicing factor 3B subunit 1 (SF3B1) [154], DNA methyltransferase 3a (DNMT3A) [155], Src homology 2 B3 (SH2B3, also named LNK) [156], and JAK2 [157] are considered to be associated with thrombocytosis and/or platelet hyper-reactivity.