PRKN and Parkinson disease: It should be noted that Wnt signaling is a well-known target for the activity of proteins involved in the pathogenesis of PD: in the healthy brain, LRKK2 (product of PARK8 gene) serves as a scaffold protein and positive regulator of the canonical pathways, whereas parkin (product of PARK2 gene) induces β-catenin degradation and suppression of the canonical pathway [157].