PRKN and Parkinson disease: The same phenomenon has not been reproduced in NSCs/NPCs yet, but it might be tempting to speculate that the positive effects of Wnt on dopaminergic neuron generation and survival are disrupted in PD due to the abnormal activity of parkin and the overactivity of the Wnt/β-catenin signaling pathway could be modulated via Cx43-β-catenin interactions at the plasma membrane of NSCs/NPCs.