These midbrain organoids allowed demonstrating the characteristics specific for Parkinson′s disease: impaired differentiation of progenitor cells, reduced number of differentiated dopaminergic neurons, higher number of progenitors, elevated expression of markers of mitophagy and autophagy, appearance of mitochondrial dysfunction, low viability of cells, and dysfunctional response to neuroinflammatory stimuli in LRKK2, DJ-1, or PRKN mutants [105,109,110,111]. This evidence concerns the gene PRKN and Parkinson disease.