Although oxidative stress has been shown to be involved in various neurodegenerative diseases [95], the cytopathological role of Nrf2 is multi-directional and multi-level, so that numerous potential targets in Nrf2 activation and Nrf2-driven gene transcription can be applied for the delay in onset of neurodegenerative diseases and even in the therapy of brain disorders. The gene discussed is NFE2L2; the disease is neurodegenerative disease.