Numerous preclinical and clinical studies in AD patients indicate that various phytochemicals, including naringenin, curcumin, methysticin, resveratrol, berberine, trigonelline, astaxanthin and sulforaphane, may have beneficial effects, in part, by enhancing Nrf2/Keap1/ARE pathway activity. The gene discussed is NFE2L2; the disease is Alzheimer disease.