KEAP1 and Alzheimer disease: In accordance with this finding, based on analysis of genetic variation in NFE2L2 and KEAP1 in material from hundreds of AD patients, von Otter et al. [110] demonstrated no association between the single nucleotide polymorphisms (SNPs) or haplotypes of Nrf2 and AD risk and suggested that amyloid β (Aβ) aggregates impair the Nrf2 system, not the opposite.