In agreement with a pro-hypertrophic effect of the ATX-LPA axis on cardiomyocytes, high fat-fed (60% kcal fat) obese mice with lentiviral ATX silencing in epididymal adipose tissue showed reduced cardiac hypertrophy, which was accompanied by diminished cardiac fibrosis and steatosis [58] (Table 1). This evidence concerns the gene ENPP2 and cardiac hypertrophy.