ENPP2 and obesity due to melanocortin 4 receptor deficiency: A relatively recent study examining whether ATX inhibition influences obesity-induced cardiomyopathy showed that circulating ATX levels positively correlate with the hypertrophy markers, atrial natriuretic peptide, and brain natriuretic peptide in a cohort of chow- and high fat (60% kcal fat)-fed mice [35].