CD4 and experimental autoimmune encephalomyelitis: In contrast, in experimental autoimmune encephalomyelitis (EAE), an autoimmune CD4+ T cell-mediated central nervous system inflammatory model similar to EAU, it has been hypothesized that PTX and CFA immunization induce early expansion and differentiation of encephalitogenic CD4+ T cells and promote the expansion of Th17/Th1 cells but not Th17/Treg cells [61].