BCL2 and neurodegenerative disease: It plays a significant role in neuronal apoptosis in neurodegenerative diseases by integrating death signals through Bcl-2/Bax and coordinates caspases through the release of Cytochrome C. Bcl-2 modulates the translocation of the pro-apoptotic protein Bax from the cytosol to the mitochondrial membrane, where it enhances mitochondrial membrane permeability and releases Cyt C, which further promotes pro-caspases activation [11].