The pretreatment of a mouse macrophage-like cell line, Raw 264.7, with sulfated galactocerebroside (sulfatide, SM4) was found to hinder LPS-induced TLR4 colocalization with CTxB-positive ganglioside-rich microdomains, suppressing the secretion of a sepsis mediator, high mobility group box 1 (HMGB1) [112]. This evidence concerns the gene HMGB1 and Sepsis.