Our data in human PCa [55] suggest that PCa tumors with PTEN loss have changes in the TME that could facilitate immune evasion, with a higher density of FoxP3+ Tregs and more IDO1 protein expression in the stromal and tumor compartments in PTEN-deficient tumors compared to tumors that maintained PTEN activity. The gene discussed is IDO1; the disease is posterior cortical atrophy.