NEAT1 and acute promyelocytic leukemia: Moreover, impaired hematopoietic differentiation in leukemia may also be a result of dysregulated lncRNAs, for example, HOTAIRM1 and NEAT1. As mentioned above, the lack of HOTAIRM1 suppresses the activation of HoxA1 and HoxA4, leading to granulocytic differentiation blockade in NB4 acute promyelocytic leukemia cell line [103].