Over the last decade, human transcriptome analyses have shown that lncRNAs are dynamically regulated and abnormally expressed in patients with DM, such as MALAT1, uc.48+, E330013P06, Hotair, Miat, and GAS5, and might be potential diagnostic biomarkers for DM [177,178,179,180]. This evidence concerns the gene GAS5 and diabetes mellitus.