Similar to lncATV, lncRNA lnc-Lsm3b, which is upregulated upon virus infection, blocks RIG-1 activation through binding to the CARD and helicase domain of RIG-1, limiting RIG-I ubiquitination and phosphorylation, and reducing virus-induced IFN-β and NF-κB promoter activity. This evidence concerns the gene RIGI and viral infectious disease.