STAT3 and cranioectodermal dysplasia: Studies have revealed that lnc13 levels are decreased in small intestine of CeD patients, repressing the expression of inflammatory genes (e.g., Stat1, Stat3, Traf2, Myd88, Ccl12, Il1ra) in macrophages, indicating a potential downregulation role for lnc13 in the pathogenesis of CeD [135].