Nonetheless, emerging pre-clinical data suggest that Δ9-THC leads to placental insufficiency, early cardiac deficits, dysglycemia (i.e., glucose intolerance, blunted insulin signaling) and dyslipidemia (i.e., augmented hepatic triglycerides, and visceral adiposity) in adult offspring [81,82,104,131,148] (Figure 3). The gene discussed is INS; the disease is placental insufficiency.