PPIF and diabetes mellitus: Based on the results of this work, one can conclude that targeting cyclophilin D and the MPT pore by alisporivir improves the ultrastructure and functioning of skeletal muscle mitochondria in diabetes, and the suppression of oxidative stress associated with the MPT pore opening may underlie the protective action of alisporivir against mitochondrial dysfunction in the skeletal muscles in diabetes mellitus.