PPIF and diabetes mellitus: The increase in the Ca2+ capacity upon the administration of alisporivir to the diabetic mice may be associated with both the direct action of this compound on mitochondria and its effect on the expression of the proteins that build up the MPT pore, namely ATP synthase, ANTs, and cyclophilin D. As mentioned above, the induction of diabetes mellitus in the experimental mice was accompanied by a decrease in the ATP synthase (both at the level of protein and mRNA).