There is also evidence that herbal decoctions containing emodin and other active substances, such as baicalein, renin or chrysin, have an effect on suppressing the expression of mRNA and toll like receptor 4 (TLR4)/NLRP3 proteins associated with the pro-inflammatory signaling pathway, which ameliorates acute pancreatitis [91]. This evidence concerns the gene TLR4 and acute pancreatitis.