Additionally, the colitis amelioration was associated with the suppression of proinflammatory cytokines (e.g., TNF-α, IL-1β, IL-6, IL-12, IL-23, IFN-γ, and IL-17) and the enhanced expression of intestinal junction proteins (e.g., claudin-1 and zonula occludens) in inflamed colons [24]. This evidence concerns the gene IFNG and colitis.