FOXO1 and Hyperglycemia: Chronic hyperglycaemia induces glucotoxicity causing islet-chronic inflammation [94,95] and PRC2 deflective function [96], resulting in β cells trans-differentiation via MafA, Nkx6.1, FoxO1, Pdx1 identity markers down-regulation [94,97,98] as well as expression of molecules only found in HEPC like Ngn3, Oct4, L-Myc or aldehyde dehydrogenase-1 isoform A3 (ALDH1A3) [99], coming in the immature, non-secreting form of a pancreatic endocrine cell.