Nevertheless, multiple studies have reported that an elevation of Interleukin 6 (IL-6) circulating levels in T2DM adult mice is possibly linked with an expansion of α cell mass and hyperglucagonemia [64], suggesting that α cell proliferation in Type 1 Diabetes Mellitus (T1DM) is probably IL-6-dependent [81]. Here, IL6 is linked to type 1 diabetes mellitus.