SIRT1 and Hyperglycemia: In this sense, Zhang et al. [85] reported that the activation of the Sirtuin 1 (SIRT1) pathway, by the administration of a positive allosteric modulator, in a streptozotocin model of T1DM, leads to an improvement of hyperglycaemia and hyperglucagonemia, as well as a reduction of α cell proliferation.