We recently demonstrated that the thymic release of CD45RA+CD31+-recent thymic emigrant (RTE)-Tregs/Tresps may be disturbed under special pathological conditions such as renal insufficiency, forcing the already distributed RTE-Tregs/Tresp to differentiate more intensely into CD45RA−CD31−-memory Tregs/Tresps (CD31−-memory-Tregs/Tresps). The gene discussed is PECAM1; the disease is Renal insufficiency.