Probably this leads to a significant age-independent increase in the proportion of ICOS+-Treg within the total CD4+-T-helper cell pool in SLE remission patients (Figure 2L), while with age, only direct proliferation of the RTE-Tregs via MN-Tregs was ascertained for these patients (Figure 2G, pathway 2). The gene discussed is ICOS; the disease is systemic lupus erythematosus.