MiR-342-3p is a tumor suppressor co-regulated with its host gene, EVL, by promoter DNA methylation in B-cell lymphomas including MCL. Re-expression of miR-342-3p and EVL and the tumor suppressor function of miR-342-3p were demonstrated by the inhibition of cellular proliferation and increase of cell death. This evidence concerns the gene EVL and B-cell non-Hodgkin lymphoma.