Mice induced with DSS- or TNBS-induced colitis receiving the HTR4 agonist tegaserod by enema exhibited improvement in disease severity in comparison to wild-type mice with inhibited HTR4 or HTR4−/− mice, which was associated with upregulated proliferation and migration of colonic epithelial cells and decreased apoptosis caused by oxidative stress [127]. This evidence concerns the gene HTR4 and colitis.